25 articles

Supplement Reviews

Evidence-based reviews of longevity supplements, tested and ranked by our research team.

Urolithin A (Mitopure): The Mitophagy Compound With Real Human Trial Data

Urolithin A is one of the few longevity compounds with multiple published human RCTs behind it — improved muscle strength, endurance, and immune cell function. Here's what four separate trials actually show, and what they don't.

Dr. James Okafor4 min read

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77/100

Curcumin for Longevity: Strong Anti-Inflammatory Evidence, But Bioavailability Is Everything

A meta-analysis of nearly 6,000 participants shows curcumin meaningfully lowers CRP, IL-6, and TNF-α. But standard turmeric supplements barely absorb — here's which formulations actually work and why the delivery system matters more than the dose.

4 min readRead article

61/100

Lithium Orotate & NDGA: The Two Compounds Bryan Johnson Added to Blueprint in 2026

Bryan Johnson dropped rapamycin and added microdose lithium orotate plus NDGA to his Blueprint stack in 2026. Here's what the evidence actually says about both — and why one is backed by mouse data and the other by drinking-water epidemiology.

5 min readRead article

87/100

Gut Health and Longevity: The Microbiome Connection Beyond Probiotics

The gut microbiome isn't just about digestion — it regulates immunity, inflammation, brain function, and biological ageing. This is the deep dive into what the evidence shows and how to build a longevity-supporting gut.

8 min readRead article

86/100

Rapamycin for Longevity: The mTOR Inhibitor That Extended Lifespan in Every Species Tested

Rapamycin is the only drug that has reproducibly extended lifespan in mammals when given late in life. It's the most discussed longevity drug in serious research circles. Here's the evidence and the honest risk assessment.

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Peptides for Longevity: BPC-157, TB-500, Epithalon, and What the Evidence Shows

Peptide therapy is the frontier of longevity medicine — used extensively in elite sports medicine and anti-aging clinics. Here's an honest guide to the evidence, risks, and regulatory status.

9 min readRead article

91/100

NAD+ Boosters: NMN, NR, Niacin — The Complete Guide to Raising NAD+

NAD+ declines 50% between age 20 and 60. Every longevity pathway — sirtuins, PARP, mitochondrial function — depends on it. Here's the science of raising NAD+ and which approach actually works.

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81/100

Collagen Supplements: What the Science Says About Joints, Skin, and Longevity

Collagen is the most abundant protein in the body. Supplementation has genuine evidence for joint pain and skin elasticity — but the mechanism is counterintuitive. Here's what actually works and what doesn't.

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82/100

Quercetin and Fisetin: The Senolytic Supplements That Clear Zombie Cells

Senescent cells — 'zombie cells' that refuse to die — drive ageing and age-related disease. Quercetin and fisetin are the most accessible senolytics available. Here's the evidence and the exact protocol.

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84/100

Berberine vs Metformin: Nature's Metformin or Overhyped Supplement?

Berberine has been called 'nature's metformin' — an OTC compound with similar AMPK-activating mechanisms. The comparison is legitimate but the nuances matter. Here's the full head-to-head.

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Alpha-Lipoic Acid: The Universal Antioxidant With a Nuanced Longevity Profile

Alpha-lipoic acid works in both fat and water — making it uniquely versatile among antioxidants. Strong evidence for metabolic health and neuroprotection. But the longevity picture is more complex than supplement labels suggest.

6 min readRead article

80/100

Metformin for Longevity: The TAME Trial, the Evidence, and What Doctors Actually Think

Metformin is the world's most prescribed diabetes drug — and potentially the first drug to be formally tested as a longevity intervention. Here's the honest evidence and the ongoing debate.

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88/100

Lion's Mane Mushroom: The NGF-Boosting Fungus With Real Clinical Data

Lion's mane is the only natural compound known to stimulate nerve growth factor synthesis in the brain. Here's the full science, optimal dosing, and what to look for in a supplement.

7 min readRead article

87/100

Taurine: The 2023 Nature Study That Changed Everything

A 2023 Nature paper found taurine deficiency drives ageing across species — and supplementation extended lifespan in mice by 12%. Here's what it means and whether you should supplement.

6 min readRead article

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Resveratrol vs Pterostilbene: Which Sirtuin Activator Is Worth Taking?

Resveratrol put longevity supplements on the map. Pterostilbene is its more bioavailable cousin. Here's what the science actually shows — and which one to take.

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84/100

Spermidine: The Autophagy-Boosting Compound With Surprising Longevity Data

Spermidine is one of the few compounds shown to extend lifespan in multiple organisms AND have human observational data. Here's what the science says.

4 min readRead article

87/100

Best CoQ10 Supplements: Ubiquinol vs Ubiquinone — Which Form Works?

CoQ10 is essential for mitochondrial energy production and declines with age. If you take a statin, you need it. Here's the evidence and which form actually absorbs.

4 min readRead article

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Rapamycin for Longevity: The Most Promising (and Controversial) Anti-Aging Drug

Rapamycin extends lifespan in every organism tested — including middle-aged mice by 25%. Here's what we know, what we don't, and what physicians are actually doing.

6 min readRead article

86/100

Best Ashwagandha Supplements: KSM-66 vs Sensoril vs Standard Root

Ashwagandha is one of the few adaptogens with solid RCT data — for cortisol, anxiety, testosterone, and sleep. Here's what the research shows and which form to buy.

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89/100

Best Berberine Supplements: The Natural Metformin Alternative

Berberine activates AMPK, lowers blood sugar as effectively as metformin, and has compelling anti-ageing data. We rank the best supplements and explain the science.

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Best Vitamin D3 + K2 Supplements: Dosing, Forms & What to Look For

Vitamin D deficiency affects over 40% of adults. But taking D3 without K2 is a mistake. Here's the evidence-based guide to the most important vitamin stack.

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Best Magnesium Supplements: Glycinate vs L-Threonate vs Malate Compared

Magnesium deficiency affects 68% of adults. The form you take determines where it works. We rank the best magnesium supplements for sleep, brain, and energy.

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Best Creatine Supplements for Longevity: Muscle, Brain & Performance

Creatine is the most researched supplement in history. We rank the best forms for longevity — muscle preservation, cognitive function, and cellular energy.

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Best NMN Supplements of 2024: Expert-Tested & Ranked

We tested 12 NMN supplements for purity, bioavailability, and value. Here are the only ones worth buying.

1 min readRead article

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Best Omega-3 Fish Oil Supplements: Ranked by Purity & Potency

Most fish oil supplements fail purity tests. We identified the ones that deliver on their label claims.

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